Technology

IT’S ALL IN YOUR HEAD:

REVIEW: of I Heard There Was a Secret Chord: Music as Medicine by Daniel J. Levitin (Reviewed by Karl Straub, December 18, 2024, Washington Independent Review of Books)

The big story throughout the book is that different elements of music are processed by different circuits in our brains, and the separate pieces of information are collated and then transferred to new circuits in order to process more complex aspects of the music. Details about pitch, duration, and loudness are stored early on, and the cooperating chain of brain departments eventually turns to complicated issues like the shape of a melody, the sonic character of instruments, and the emotional connections for the listener.

Few human activities compare to listening to music — although hikes in the wild and dancing are distant siblings — with its epic journey of interoffice memos linking both a network of small circuits and the often-isolated two hemispheres of the brain. It’s this sweeping process that leads to medicinal and therapeutic benefits; listening to music can open up alternate neural pathways to substitute for burned-out or dormant ones, and it can also rejuvenate paths exhausted by stress.

Among the book’s other fascinating takeaways: Playing music or singing decreases levels of the stress hormone cortisol, leaving us more relaxed. Children get attached to inanely catchy songs like “Baby Shark” because the repetition of musical information is building the brain pathways they’ll need to enjoy the greater benefits of music later on. Because adults already built their own pathways in childhood, these songs often drive them crazy. (Take heart, Mom and Dad: They really are good for the kids.)

For most music-therapy applications (stress/pain relief, mood alteration, and treating complex neurological dysfunction), the best results happen when the listener picks music they already love. (This means Zell Miller was onto something with his Charlie Daniels theory.) But it’s also true that increased understanding of how music works helps lead to improvements in brain health, even for non-virtuosos. In other words, musical comfort food and the musical equivalent of high fiber are both good for you.

COVID RESTRICTIONS WERE TOO LAX:

Estimating the population-level effects of nonpharmaceutical interventions when transmission rates of COVID-19 vary by orders of magnitude from one contact to another (Richard P. Sear, 12/03/24, Phys. Rev. E )

Statistical physicists have long studied systems where the variable of interest spans many orders of magnitude, the classic example is the relaxation times of glassy materials, which are often found to follow power laws. A power-law dependence has been found for the probability of transmission of COVID-19, as a function of length of time a susceptible person is in contact with an infected person. This is in data from the United Kingdom’s COVID-19 app. The amount of virus in infected people spans many orders of magnitude. Inspired by this, I assume that the power-law behavior found in COVID-19 transmission is due to the effective transmission rate varying over orders of magnitude from one contact to another. I then use a model from statistical physics to estimate that if a population all wear FFP2/N95 masks, this reduces the effective reproduction number for COVID-19 transmission by a factor of approximately nine.

WHAT HAVE VACCINES EVER DONE FOR US?:

Cervical cancer deaths are plummeting among young U.S. women: The findings could be a preview of what’s to come if HPV vaccination rates improve (Andrea Tamayo, November 27, 2024, Science News)

“We had a hypothesis that since it’s been almost 16 years, that maybe we might be starting to see [the] initial impact of HPV vaccination on cervical cancer deaths,” says Ashish Deshmukh, an epidemiologist at the Medical University of South Carolina in Charleston. “And that’s exactly what we observed.”

Just another reason for the incel Right to hate vaccines.

NOT JUST SHOWER CURTAIN RINGS?:

New 3D Bioprinter Could Build Replicas of Human Organs, Offering a Boost for Drug Discovery (Margherita Bassi, November 19, 2024, Smithsonian)

Currently, scientists have only limited ways to create tissue for testing pharmaceutical therapies, such as using lab-grown samples or by relying on traditional 3D bioprinting, per Popular Science’s Andrew Paul. However, cultivating organs in a lab is complex and expensive—and printing them is currently slow and prone to errors, such as positioning cells incorrectly.

“Incorrect cell positioning is a big reason most 3D bioprinters fail to produce structures that accurately represent human tissue,” David Collins, head of the Collins BioMicrosystems Laboratory at the University of Melbourne and a co-author of the study, says in a statement.

“But with our new approach,” Collins and two other researchers write in an article for Pursuit, “not only can we position cells with precision, we can also fabricate at a scale of single cells.”