Technology

“Across recent studies, people with IBS who believe they’re gluten-sensitive react similarly to gluten, wheat, and placebo,” said Biesiekierski. “This suggests that how people anticipate and interpret gut sensations can strongly influence their symptoms.”

[W]e looked at clinical outcomes for more than 1,000 late-stage melanoma and lung cancer patients treated with a type of immunotherapy called immune checkpoint inhibitors. This treatment is a common approach doctors use to train the immune system to kill cancer. It does this by blocking a protein that tumor cells make to turn off immune cells, enabling the immune system to continue killing cancer.

Remarkably, patients who received either the Pfizer or Moderna mRNA-based COVID-19 vaccine within 100 days of starting immunotherapy were more than twice as likely to be alive after three years compared with those who didn’t receive either vaccine. Surprisingly, patients with tumors that don’t typically respond well to immunotherapy also saw very strong benefits, with nearly fivefold improvement in three-year overall survival. This link between improved survival and receiving a COVID-19 mRNA vaccine remained strong even after we controlled for factors like disease severity and co-occurring conditions.

To understand the underlying mechanism, we turned to animal models. We found that COVID-19 mRNA vaccines act like an alarm, triggering the body’s immune system to recognize and kill tumor cells and overcome the cancer’s ability to turn off immune cells. When combined, vaccines and immune checkpoint inhibitors coordinate to unleash the full power of the immune system to kill cancer cells.

For the new study, researchers compared social experiences across the lifespan of more than 2,100 middle-aged adults in the United States to the biological clock embedded in their DNA. The hands of these biological clocks consist of epigenetic changes to DNA—specifically, patterns in the addition of a chemical called a methyl group to certain genes. Such methylation doesn’t cause mutation; rather, the process turns the gene on or off in different cells of the body at different times. Over time, methylation patterns on certain genes change and can be used as markers of biological aging, a measure of how rapidly cells wear down that can be faster or slower than aging by the calendar. An older biological age is a strong predictor of chronic disease and early death.

The researchers measured social connection in a variety of settings over time to show that people with more social activity and sincere, long-lasting relationships aged more slowly. “We found that the depth and consistency of social connection, built across decades and different areas of life, matters profoundly,” says Anthony Ong, a psychologist at Cornell University. “Strong and sustained social networks appear to actually set back a person’s biological clock.”

Alongside these pain assessments using traditional methods, the researchers tested their “monetary equivalence” (ME) method. Participants were repeatedly asked whether they would accept a certain amount of money to experience the same painful stimulus again, or choose a smaller amount to avoid it. Example: “Would you rather get 15 Swiss francs and feel the pain again, or 10 Swiss francs and no pain?” The point where a participant switched from “no pain” to “pain” revealed how much the pain was “worth” to them in monetary terms. Two versions of the ME method were tested: ME1, where questions were listed in increasing order of money (enforcing consistency); and ME2, where the same questions were asked randomly (allowing for some inconsistency).

Across all three experiments, the monetary methods (ME1 and ME2) outperformed the traditional scales at distinguishing between high- and low-pain conditions. Effect sizes – that is, how strongly the measure distinguished between groups – were dramatically larger for ME1 and ME2 (“very large”) compared to standard pain scales (“small to medium”). Even in the analgesic study, where traditional scales often failed or even showed misleading results (for example, participants reporting more pain after receiving an analgesic), the monetary measures correctly and significantly detected differences. This likely happened because participants expected the anesthetic to eliminate the pain completely, and when it didn’t, they rated their pain higher. It’s a psychological effect the monetary method avoids.