A RANGE OF PLACEBOES:
64 widely available “mood-boosting” supplements are put to the test (Bronwyn Thompson, July 14, 2025, New Atlas)
The most comprehensively studied products were omega-3s (39 trials), St John’s wort (38), prebiotics (18) and vitamin D (14) – as well as saffron (18), which is popular in the Middle East and Asia.
As far as relieving depression symptoms, there was little conclusive evidence that omega-3 supplements had any impact; the scientists found more studies produced no effects than those that showed some, compared to a placebo. In 2021, we covered one such study that failed to show omega-3 supplements played any role in treating depression.
St John’s wort and saffron had the strongest positive outcomes, with studies showing these two distinct supplements worked, compared to a placebo, and were on par with existing prescription antidepressants. And gut-health probiotics, as well as vitamin D, reduced depressive symptoms to some degree in their respective controlled trials.
But overall, the researchers found a distinct lack of multiple trials for many emerging OTC products, which shows how far the science is lagging behind as the wellbeing supplements market continues to grow. More than 40 of the 64 products had only a single clinical study completed on them to date.
Do whatever you believe will work.