GOLDBERG'S STILL GLEAMING:

New Genetics Study Undermines Gay Gene Theory (Warren Throckmorton, Ph.D. & Durwood Ray, Ph.D., 2/09/05, Grove City College)

A study to be published in the March 2005 issue of the journal Human Genetics, and available online now, actually undermines the commonly held view that homosexual orientation is determined by genetic factors. [...]

The authors describe in the article three non-X chromosomal "new regions of genetic interest” (7q36, 8p12, and 10q26). In the authors’ view, a noteworthy aspect of the study as follows: "Our strongest finding was on 7q36 with a combined mlod score of 3.45 and equal distribution from maternal and paternal allele transmission. This score falls just short of Lander and Kruglyak's (1995) criteria for genomewide significance." They go on to say "two additional regions (8p12 and 10q26) approached the criteria for suggestive linkage" - again pointing out that neither was statistically significant.

Thus, even the author’s “strongest finding” was not statistically significant by widely accepted scientific criteria.

The study also reexamined potential genetic contributions on the X chromosome from region Xq28. This is the region first identified by Dean Hamer as associated with homosexual orientation. However, this study re-analysis, to quote the authors, “did not find linkage to Xq28 in the full sample.”

The regions hypothesized as relating to sexual orientation by the research team appear to relate to developmental precursors to temperamental factors that have been associated with environmental theories of same sex attractions. For instance, one region identified is associated with hormones that impact sexual development. Another is linked to hemispheric development in the brain. Such genes may impact the temperamental traits of activity level and aggressiveness. Lower preferences for aggressive activities have been linked to the development of same sex attractions in men. However, currently there is no research evidence in the Mustanski study or any other of a direct pathway from genes to sexual attractions that does not involve environment interacting with individual temperamental differences.

Consistent with an environmental explanation of same sex attraction is the work of Daryl Bem. In a 2000 study, Dr. Bem demonstrated that there is no relationship between genotype and sexual orientation in men unless environmental interaction with the temperamental trait of gender nonconformity is taken in account. In other words, exploring individual temperamental factors lived out within certain environments may provide more precise areas for research into the action of potential genetic factors in the development of sexual attractions.

If only genetics were horseshoes...

Posted by Orrin Judd at February 10, 2005 2:51 PM