January 10, 2004
NO GAY GENE YET, BUT WE’VE JUST FOUND THE NEUROTIC NORWEGIAN GENE:
Effects of Purifying and Adaptive Selection on Regional Variation in Human mtDNA (Eduardo Ruiz-Pesini, Dan Mishmar, Martin Brandon, Vincent Procaccio, Douglas C. Wallace, Science, 09/01/04)
A phylogenetic analysis of 1125 global human mitochondrial DNA (mtDNA) sequences permitted positioning of all nucleotide substitutions according to their order of occurrence. The relative frequency and amino acid conservation of internal branch replacement mutations was found to increase from tropical Africa to temperate Europe and arctic northeastern Siberia. Particularly highly conserved amino acid substitutions were found at the roots of multiple mtDNA lineages from higher latitudes. These same lineages correlate with increased propensity for energy deficiency diseases as well as longevity. Thus, specific mtDNA replacement mutations permitted our ancestors to adapt to more northern climates, and these same variants are influencing our health today.
The full article costs a fortune, but this abstract seems to herald yet another proof of natural selection, if not a tantalizing hint of speciation. Here is how it was reported in the mainstream press:
Optimism cold comfort for chills, study says (Stephen Strauss, The Globe and Mail, 10/01/04)
Not worrying may help you be happy, but optimism won't help you endure that nastiness known as the Canadian winter.As much of the Eastern half of the country shivers and moans in a cold snap, new research suggests that the constantly carping neurotics do better at enduring winter's bitterness than generally positive-minded extroverts. [...]
The Canadian study of personality and response to weather comes a day after a report in the journal Science described a gene/cold tolerance link.
It found that many Northern Europeans, East Asians and aboriginals carry a mutation making them less susceptible to the cold than individuals coming from Africa. None of the Africans tested showed any signs of the mutation whatsoever, while up to 75 per cent of people coming from Arctic regions did.
This suggests, say the U.S. authors of the article, that the mutation helped determine who would survive when humans moved out of their African homeland 65,000 years ago and started to confront an increasingly shivery North.
All the familiar themes are here–change, movement, struggle, fitness, extinction, adaptation. So enthralled are we by yet another chapter of our favourite tale that we fail to ask whether this travel adventure isn’t rather a large logical leap to make from variations in amino acid concentrations. When our paleo-ancestors from Africa were a hankerin’ for adventure and decided to walk to the Arctic en masse, did some of them develop the gene before they left, as the Globe suggests, (excitement?) or after they arrived, as Science intimates (they must have done it bloody fast)? Why do only 75% have it today and what evidence is there of a trail of gene-challenged 65,000 year-old Africans frozen en route? How do we know they didn’t all develop it quickly and easily from food and sharp breezes (no drama there)? And why did their skin colour change?
Those who continue to challenge or even question evolution are told increasingly that science has now proven so many elements that the theory (as a self-contained explanation of existence) is now incontrovertible. If this kind of ex post facto induction is typical of the science they are talking about, the debate may have a few more millenia to go.
I've seen some mtDNA studies I'd like to believe, mostly tracing isolated populations of Jews (Ethopian, Indian, etc.) back to ancient Israel, but I don't think I've ever seen a study that didn't prove what the investigator was hoping to prove, so I'm somewhat skeptical.
Posted by: David Cohen at January 10, 2004 7:39 PMI understood that the explanation for increasingly pale northern peoples lay in the body's need for Vitamin D (or whichever vitamin it is that the body needs sunlight to synthesize). The farther north early humans got, the more oblique the sun's rays became, and thus the solar radiation they were exposed to becamse less intense. In the weaker sunlight, paleness helps the body manufacture the vitamin D it needs by allowing deeper penetration by the neccessary part of sunlight's spectrum.
The Inuits, I guess, got up north much later than the Scandanavians. Etc., etc.
Posted by: Twn at January 10, 2004 8:50 PMTwn:
The body requires sunlight to produce vitamin D. However, the obliqueness of the sun's rays is only part of the equation.
Cloud cover is the rest. Northern Europe is probably the cloudiest area on the planet.
Posted by: Jeff Guinn at January 11, 2004 12:59 PMJeff:
That makes sense, but do you believe black-skinned Africans migrated to Scandinavia and developed white skin to get more vitamin D? If so, why the blue eyes? If not, what other explanations can you think of?
Posted by: Peter B at January 11, 2004 7:13 PMPeter:
Well, they didn't get there overnight. They didn't "develop" white skin to get more Vitamin-D. Rather, there was some distribution of skin color across the population, and as people gradually moved into those areas, those on the lighter end of the bell curve were less likely to develop Vitamin-D deficiency. Therefore, they were statistically slightly more likely to leave offspring.
Heck, I don't have a clue about the why behind blue eyes.
BTW--how was your skiing holiday?
Posted by: Jeff Guinn at January 11, 2004 7:43 PMJeff:
Great, thanks, but frigid. No cold gene in this Canadian!
I know you think I am baiting you, but I'm just trying to find a story that makes sense. Are you saying blacks and whites both used to roam Scandinavia but the blacks all died off because it was too cloudy?
Also, why did everybody migrate from East Africa to such awful climes? Why didn't anybody migrate back, especially if they were all dying off in Northern Europe?
Posted by: Peter B at January 11, 2004 8:17 PMPeter:
I'm saying "blacks" never made it to Scandinavia. It took a long time to make the move from Africa into Northern Europe. By the time people made it to Scandinavia, there were no blacks, but there was a climatalogical correlation between melanin concentration and climate.
People then, I am guessing, found it easier to migrate to where people arent, then to where they are. Also, any given generation was likely to migrate just far enough to find a suitable empty territory, which probably wouldn't look very much different than what they were already used to. I can't remember for sure, but I think archeologists believe it took roughly 5,000 years for people to migrate from Alaska to Tierra del Fuego. That is only about 40 miles per generation.
Posted by: Jeff Guinn at January 11, 2004 9:49 PMJeff:
Have you ever considered how implausible is the idea that a given people would stay on the move in the same direction for forty generations? That trumps Exodus and no one ever suggested that was plausible or common or natural. How come pre-history is full of people migrating fantastic distances (often away from temperate and into hostile climates) but then they generally start to settle down when recorded history starts? (And if you say scarce game, you are making huge leaps of faith about relative human/animal populations, are you not?)
You know, like others, I am often struck by the general chronological accuracy from an evolutionary point of view of the story of Creation in Genecis. Quite unlike any other mythical cosmological history I have ever heard. The more I get into this with you, the more I see suspicious parallels with the whole Pentateuch.
Posted by: Peter B at January 12, 2004 8:56 AMmtDNA studies tell us, surprisingly, that Africans did not just walk north. They came out via the Red Sea and marched coastwise. Some ended in Australia, others in east Asia. Europe appears to have been people from the east not the south, and comparatively late. (There were, of course, premoderns humans there earlier, but we cannot do mtDNA traces to recreate their wanderings.)
If you look at a map of blondness frequencies, it is obvious where the mutation occurred -- Lithuania. The frequency diminishes uniformly in all directions from there.
Peter's question about wanderings is a good one, but there was still a lot of wandering going on in historic times. In N. America, the moves of the Tuscarora were epic.
Posted by: Harry Eagar at January 12, 2004 12:02 PMPeter:
How do ripples move?
Put differently, nature abhors a vacuum. Think about how the US evolved: essentially uniform direction in the direction of the remaining vacuum--the Native Americans failed to exert enough counterpressure.
People didn't move from temperate to harsh climates. They followed the path of least resistance from where ever they were to someplace very much like it. 40 miles/generation scarcely covers the distance from my house to my office.
Posted by: Jeff Guinn at January 12, 2004 12:38 PMHarry/Jeff:
Look, the problem is your quantum jumps from general observations to full-blown detailed history. Obviously there are connections between climate and skin-colour, but there are a lot of exceptions too (Why do Middle-Easterners have lighter skins than African jungle dwellers? They suffer a lot more direct sun). Ditto for nomadic movements, which obviously occurred. But you guys seem to have everybody in perpetual long distance travel to set up the mutations. Does this mean man is now going to stop mutating if we all stay close to home? Are you really confident you are playing skeptical scientist here and not sqeezing the evidence into the theory?
Harry, how does one take a coastal route from the Red Sea to Lithuania for the gene makeover? Via Spain? Everybody passed through Lithuania? It must be a paleontologist's heaven. (Is it?) North American Indians may have ranged far and wide, but Alaska to Tierra del Fuego? I know precious little about this, but I have seen Inuit migration patterns and they seem to have spent a lot of time travelling in circles and never left the Arctic.
Posted by: Peter B at January 12, 2004 5:03 PMEurope was settled from the east. The mutation arose in Lithuania. What is so difficult to understand about that?
In the US westward movement, people strongly tended to move on along the same latitude they started from -- Tennesseans went to Texas, Ohioans to Iowa. We don't expect a genetic or darwinian explanation for that. People behave like people.
Posted by: Harry Eagar at January 12, 2004 5:48 PMEurope was settled from the east. The mutation arose in Lithuania. What is so difficult to understand about that?
In the US westward movement, people strongly tended to move on along the same latitude they started from -- Tennesseans went to Texas, Ohioans to Iowa. We don't expect a genetic or darwinian explanation for that. People behave like people.
Posted by: Harry Eagar at January 12, 2004 5:48 PMHarry:
Tennesseans went to Texas as individuals in response to conscious desires, not collectively to survive. Did they mutate as they passed through Arkansas?
Posted by: Peter B at January 12, 2004 9:39 PMPeter:
Your exceptions aren't really exceptions, but rather variations within a type.
Finding light skinned, blue-eyed, blond natives in equatorial regions would be an exception. There aren't any of those.
I'll bet if you looked at bacterial migration patterns in agar, and human migration patterns on a map, a great many similarities would arise. Among them that migration tends to be radial--as Harry noted--rather than lateral. Radial is the path of least resistance.
And not all members of a population migrate. Of the first inhabitants of Alaska who remained behind, what reason was there to go anywhere?
Posted by: Jeff Guinn at January 13, 2004 7:34 AMJeff:
What is the difference between an exception and a variation?
Posted by: Peter B at January 13, 2004 9:20 AMBingo, Peter. Only occasionally do whole populations move. Individuals or families go to Texas. If Texas is empty, they multiply greatly.
So, for example, there are more English speakers in America than in England. David Hackett Fischer has a great deal about the tremendous population explosion of the early English colonists in, say, Delaware in "Albion's Seed.'
Posted by: Harry Eagar at January 13, 2004 11:36 AMPeter:
In general, at any given latitude, people have darker skins than at a more northerly latitude. Skin color is not identical at any given latitude; Yemenis are lighter skinned than Africans. But all Yeminis and all Africans are darker skinned than Italians.
That is variation.
An exception would be a discontinuity in the variation. Finding very dark skinned people in a northerly latitude, in contrast to the otherwise observed variation, is an exception. Finding dark skinned people in an area with limited sunlight, or light skinned people in an area with extensive sunlight, would also be an exception.
There may very well be some of those, but none to my very limited knowledge.
Posted by: Jeff Guinn at January 13, 2004 12:48 PM