January 7, 2018

NO ONE WILL MISS JOBS:

Is everything you think you know about depression wrong? : In this extract from his new book, Johann Hari, who took antidepressants for 14 years, calls for a new approach (Johann Hari, Sun 7 Jan '18, The Guardian)

We all know that when you take selfies, you take 30 pictures, throw away the 29 where you look bleary-eyed or double-chinned, and pick out the best one to be your Tinder profile picture. It turned out that the drug companies - who fund almost all the research into these drugs - were taking this approach to studying chemical antidepressants. They would fund huge numbers of studies, throw away all the ones that suggested the drugs had very limited effects, and then only release the ones that showed success. To give one example: in one trial, the drug was given to 245 patients, but the drug company published the results for only 27 of them. Those 27 patients happened to be the ones the drug seemed to work for. Suddenly, Professor Kirsch realised that the 70% figure couldn't be right.

It turns out that between 65 and 80% of people on antidepressants are depressed again within a year. I had thought that I was freakish for remaining depressed while on these drugs. In fact, Kirsch explained to me in Massachusetts, I was totally typical. These drugs are having a positive effect for some people - but they clearly can't be the main solution for the majority of us, because we're still depressed even when we take them. At the moment, we offer depressed people a menu with only one option on it. I certainly don't want to take anything off the menu - but I realised, as I spent time with him, that we would have to expand the menu.

This led Professor Kirsch to ask a more basic question, one he was surprised to be asking. How do we know depression is even caused by low serotonin at all? When he began to dig, it turned out that the evidence was strikingly shaky. Professor Andrew Scull of Princeton, writing in the Lancet, explained that attributing depression to spontaneously low serotonin is "deeply misleading and unscientific". Dr David Healy told me: "There was never any basis for it, ever. It was just marketing copy."

I didn't want to hear this. Once you settle into a story about your pain, you are extremely reluctant to challenge it. It was like a leash I had put on my distress to keep it under some control. I feared that if I messed with the story I had lived with for so long, the pain would run wild, like an unchained animal. Yet the scientific evidence was showing me something clear, and I couldn't ignore it.

So, what is really going on? When I interviewed social scientists all over the world - from São Paulo to Sydney, from Los Angeles to London - I started to see an unexpected picture emerge. We all know that every human being has basic physical needs: for food, for water, for shelter, for clean air. It turns out that, in the same way, all humans have certain basic psychological needs. We need to feel we belong. We need to feel valued. We need to feel we're good at something. We need to feel we have a secure future. And there is growing evidence that our culture isn't meeting those psychological needs for many - perhaps most - people. I kept learning that, in very different ways, we have become disconnected from things we really need, and this deep disconnection is driving this epidemic of depression and anxiety all around us.

Let's look at one of those causes, and one of the solutions we can begin to see if we understand it differently. There is strong evidence that human beings need to feel their lives are meaningful - that they are doing something with purpose that makes a difference. It's a natural psychological need. But between 2011 and 2012, the polling company Gallup conducted the most detailed study ever carried out of how people feel about the thing we spend most of our waking lives doing - our paid work. They found that 13% of people say they are "engaged" in their work - they find it meaningful and look forward to it. Some 63% say they are "not engaged", which is defined as "sleepwalking through their workday". And 24% are "actively disengaged": they hate it.

Most of the depressed and anxious people I know, I realised, are in the 87% who don't like their work. I started to dig around to see if there is any evidence that this might be related to depression. It turned out that a breakthrough had been made in answering this question in the 1970s, by an Australian scientist called Michael Marmot. He wanted to investigate what causes stress in the workplace and believed he'd found the perfect lab in which to discover the answer: the British civil service, based in Whitehall. This small army of bureaucrats was divided into 19 different layers, from the permanent secretary at the top, down to the typists. What he wanted to know, at first, was: who's more likely to have a stress-related heart attack - the big boss at the top, or somebody below him?

Everybody told him: you're wasting your time. Obviously, the boss is going to be more stressed because he's got more responsibility. But when Marmot published his results, he revealed the truth to be the exact opposite. The lower an employee ranked in the hierarchy, the higher their stress levels and likelihood of having a heart attack. Now he wanted to know: why?

And that's when, after two more years studying civil servants, he discovered the biggest factor. It turns out if you have no control over your work, you are far more likely to become stressed - and, crucially, depressed. Humans have an innate need to feel that what we are doing, day-to-day, is meaningful. 

Labor was a punishment from God, and that was productive labor.  Your make-work job in the modern economy is the last place you should look for meaning.

Posted by at January 7, 2018 11:41 AM

  

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