August 27, 2015

HYGIENE, NUTRITION, ANTIBIOTICS AND VACCINES:

'Major step' towards universal flu vaccine, studies say (AFP, 25 August 2015)

Scientists have long known that the stem of haemagglutinin - a spike-like protein, known as HA, on the surface of the virus - remains largely the same even when the tip, or "head", changes.

But until now, they have not been able to use the stem to provoke an immune reaction in lab animals or humans that would either neutralise the virus, or allow the body to attack and destroy infected cells.

To make that happen, a team led by Hadi Yassine of the Vaccine Research Center at the US National Institutes of Health grafted a nano-particle-sized protein called ferritin onto a headless HA stem.

The next step was to immunise mice and ferrets, then injecting them with the H5N1 "bird flu" that has a mortality rate of more than 50% among people but is not very contagious.

The mice were completely protected against the flu, the researchers found.

And most of the ferrets, the species that best predicts the success of influenza vaccines on humans, did not fall ill either.

Moreover, when a new batch of mice was injected with antibodies from the rodents which had survived the previous round, most of them also shook off what should have been a lethal dose of bird flu.

The other study, led by Antonietta Impagliazzo of the Crucell Vaccine Institute in Leiden, the Netherlands, took a similar approach - also creating an HA "stem-only" vaccine.


Posted by at August 27, 2015 5:08 PM
  

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